
GR 46611
CAS No. 185259-85-2
GR 46611( —— )
Catalog No. M27631 CAS No. 185259-85-2
GR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
5MG | 76 | Get Quote |
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10MG | 123 | Get Quote |
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25MG | 250 | Get Quote |
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50MG | 399 | Get Quote |
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100MG | 581 | Get Quote |
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200MG | Get Quote | Get Quote |
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500MG | Get Quote | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameGR 46611
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NoteResearch use only, not for human use.
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Brief DescriptionGR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy.
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DescriptionGR 46611 is a selective 5-HT1B and 5-HT1D receptor agonist and can be used in studies about the treatment of epilepsy.(In Vivo):GR 46611 (0.6 and 6 nmol; paraventricular hypothalamic nucleus (PVN)) promptly and reliably elicited feeding at their higher doses, without affecting drinking or non-ingestive behaviors. GR 46611 (6 nmol) elicited intense feeding responses in the n. medialis hypothalami posterioris and in the adjacent n. lateralis hypothalami posterioris (PMH/PLH complex, in the caudoventral hypothalamus) and in the n. magnocellularis preopticus (PPM, in the caudal preoptic region). GR 46611 (1 mg/kg) significantly increased the threshold of hyperthermia-induced seizure and lowered seizure severity thereby improving the survival of DS mice.
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In VitroGR-46611 (1 μM, 48 h) induces CEM cell proliferation. Cell Proliferation Assay Cell Line:CEM cells (human T lymphoblastic leukemia cell line)Concentration:1 μM Incubation Time:48 h Result:Induced a significant increase in cell proliferation by 37.0%.
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In VivoGR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice.GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats.GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig. Animal Model:Dravet syndrome (DS) mice Dosage:0.01, 0.1 and 1 mg/kg Administration:Intraperitoneal injection (i.p.)Result:Improved survival relative to vehicle treated controls with 89% surviving rate.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number185259-85-2
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Formula Weight377.488
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Molecular FormulaC23H27N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (264.91 mM)
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SMILESCOc1ccc(CNC(=O)\C=C/c2ccc3[nH]cc(CCN(C)C)c3c2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Moisés Laparra J, et al. Kojibiose ameliorates arachidic acid-induced metabolic alterations in hyperglycaemic rats. Br J Nutr. 2015 Nov 14;114(9):1395-402.
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